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Medi-Cal Rx - Statewide Pharmacy Program


Medi-Cal Rx is the administration of Medi-Cal Pharmacy Benefits through the fee-for-service delivery system.  Full Medi-Cal Rx implementation began January 1, 2022.  

For more information:

For assistance, call the Medi-Cal Rx Customer Service Center at:

(800) 977-2273.  24 Hours a day, 7 days a week, 365 days per year.


Medi-Cal Rx began January 1st


As of January 1, 2022, all pharmacy benefits will transition away from CA-MMIS and the Medi-Cal managed care plans to Medi-Cal Rx. This transition will create a uniform process for pharmacy providers and prescribers and applies to everyone in Medi-Cal FFS and managed care. All benefits that are billed on a pharmacy claim will be transitioned to Medi-Cal Rx and all Prior Authorizations (PA) will be reviewed by Medi-Cal Rx starting on January 1.  

To prepare for Medi-Cal Rx, we encourage you to visit the robust Medi-Cal Rx Education & Outreach page on the Medi-Cal Rx Web Portal to unlock all the training opportunities and informative materials that are currently available. The Medi-Cal Rx YouTube Channel offers training videos, including a video on the transition and the resources that directly impact pharmacy providers and prescribers. We also offer live, instructor-led trainings or join us for an Office Hour Luncheon Session available Monday-Friday, 12 p.m. to 1 p.m. PST (excluding holidays).  

Medi-Cal Rx is designed to improve your experience with Medi-Cal. Medi-Cal Rx has created a uniform and searchable Contracts Drug List (CDL) for all beneficiaries, it opens up the network to include all pharmacies and has a robust Transition Policy which includes “grandfathering” for previously approved PAs and a 180-day period where DHCS will not require PA for existing prescriptions in order to provide a seamless beneficiary experience.  Medi-Cal Rx also has 24-hour a day, 365 days a year customer service center available to assist prescribers, pharmacy providers, beneficiaries, our managed care partners and others. 

Please visit the Medi-Cal Rx Provider Portal Forms & Information page to find these available resources: 

Be sure to subscribe to the Medi-Cal Rx Subscription Service (MCRxSS) to stay up to date with the latest Medi-Cal Rx news. For questions, please contact the Medi-Cal Rx Customer Service Center at 1-800-977-2273, available 24 hours a day, 365 days a year or email us at

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